Synergistic Anticancer Potential of Dichloroacetate and Estradiol Analogue Exerting their Effect via ROS-JNK-Bcl-2-Mediated Signalling Pathways

Synergistic Anticancer Potential of Dichloroacetate and Estradiol Analogue Exerting their Effect via ROS-JNK-Bcl-2-Mediated Signalling Pathways

Background: C9, a newly in silico-designed inhibitor of microtubule dynamics induces G2/M arrest culminating in apoptosis. Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase, an enzyme that promotes pyruvate entry into mitochondria. The use of antitumor drugs targeting different cancer fea...

Full description

Bibliographic Details
Main Authors: Xiao Xing Stander, Barend André Stander, Annie Margaretha Joubert
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Combination treatment
Antimitotic
DCA
MCF-7
MCF-12A
Apoptosis
Autophagy
JNK
Bcl-2 and ROS
Online Access:http://www.karger.com/Article/FullText/369710

Internet

http://www.karger.com/Article/FullText/369710

Similar Items