Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice

Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice

Abstract Background Tuberous sclerosis complex 1 (Tsc1) is known to regulate the development and function of various cell types, and RORγt is a critical transcription factor in the immune system. However, whether Tsc1 participates in regulating RORγt-expressing cells remains unknown. Methods We gene...

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Bibliographic Details
Main Authors: Yafei Deng, Qinglan Yang, Yao Yang, Yana Li, Hongyan Peng, Shuting Wu, Shuju Zhang, Baige Yao, Shuhui Li, Yuan Gao, Xiaohui Li, Liping Li, Youcai Deng
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Neuroinflammation
Subjects:
RORγt-expressing cells
Tsc1
GABA
Seizure
Online Access:https://doi.org/10.1186/s12974-021-02153-8

Internet

https://doi.org/10.1186/s12974-021-02153-8

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