Obacunone Protects Against Ulcerative Colitis in Mice by Modulating Gut Microbiota, Attenuating TLR4/NF-κB Signaling Cascades, and Improving Disrupted Epithelial Barriers

Obacunone Protects Against Ulcerative Colitis in Mice by Modulating Gut Microbiota, Attenuating TLR4/NF-κB Signaling Cascades, and Improving Disrupted Epithelial Barriers

Obacunone, a natural limonoid compound abundantly distributed in citrus fruits, possesses various biological properties, such as antitumor, antioxidant, and antiviral activities. Recent studies suggested an anti-inflammatory activity of obacunone in vitro, but its efficacy on intestinal inflammation...

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Bibliographic Details
Main Authors: Xiaoping Luo, Bei Yue, Zhilun Yu, Yijing Ren, Jing Zhang, Junyu Ren, Zhengtao Wang, Wei Dou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Microbiology
Subjects:
UC
gut microbiota
TLR4/NF-κB
epithelial barrier
obacunone
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00497/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00497/full

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