Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway

Early Developmental Exposure to General Anesthetic Agents in Primary Neuron Culture Disrupts Synapse Formation via Actions on the mTOR Pathway

Human epidemiologic studies and laboratory investigations in animal models suggest that exposure to general anesthetic agents (GAs) have harmful effects on brain development. The mechanism underlying this putative iatrogenic condition is not clear and there are currently no accepted strategies for p...

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Bibliographic Details
Main Authors: Jing Xu, R. Paige Mathena, Michael Xu, YuChia Wang, CheJui Chang, Yiwen Fang, Pengbo Zhang, C. David Mintz
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
anesthesia
neurotoxicity
synapse
mTOR
neurodevelopment
Online Access:http://www.mdpi.com/1422-0067/19/8/2183

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http://www.mdpi.com/1422-0067/19/8/2183

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