Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits

Mouse-adapted scrapie strains have been characterized by vacuolation profiles and incubation times, but the behavioral consequences have not been well studied. Here, we compared behavioral impairments produced by ME7, 79A, 22L, and 22A strains in C57BL/6J mice. We show that early impairments on burr...

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Bibliographic Details
Main Authors: C. Cunningham, R.M.J. Deacon, K. Chan, D. Boche, J.N.P. Rawlins, V.H. Perry
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002104