Evaluation of the human type 3 adenoviral dodecahedron as a vector to target acute myeloid leukemia

Evaluation of the human type 3 adenoviral dodecahedron as a vector to target acute myeloid leukemia

Intensive systemic chemotherapy is the gold standard of acute myeloid leukemia (AML) treatment and is associated with considerable off-target toxicities. Safer and targeted delivery systems are thus urgently needed. In this study, we evaluated a virus-like particle derived from the human type 3 aden...

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Bibliographic Details
Main Authors: Benjamin Caulier, Gaëlle Stofleth, Dalil Hannani, Mélanie Guidetti, Véronique Josserand, David Laurin, Jadwiga Chroboczek, Pascal Mossuz, Dominique Plantaz
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
adenoviral dodecahedron
virus-like particles
acute myeloid leukemia
leukemic stem cells
delivery vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120302369

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http://www.sciencedirect.com/science/article/pii/S2329050120302369

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