TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

The pattern recognition receptor toll-like receptor (TLR)-4 mediates innate danger signaling in the brain, being activated in response to lipopolysaccharide. Until now, its role in the degenerating brain remained unknown. We here examined effects of a loss-of-function mutation of TLR-4 in mice submi...

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Bibliographic Details
Main Authors: Ulkan Kilic, Ertugrul Kilic, Christian M. Matter, Claudio L. Bassetti, Dirk M. Hermann
Format: Article
Language:English
Published: Elsevier 2008-07-01
Series:Neurobiology of Disease
Subjects:
Innate immune system
Danger signaling
Ischemic stroke
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000508

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http://www.sciencedirect.com/science/article/pii/S0969996108000508

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