Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells
The iron-regulated F-box protein FBXL5 regulates iron homeostasis by mediating the degradation of iron regulatory protein 2 (IRP2). Here the authors show that FBXL5 and its regulation of IRP2 are required for HSC self-renewal and reconstitution capability.
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms16114 |