Reconstructing cell cycle pseudo time-series via single-cell transcriptome data

In single-cell RNA sequencing data of heterogeneous cell populations, cell cycle stage of individual cells would often be informative. Here, the authors introduce a computational model to reconstruct a pseudo-time series from single cell transcriptome data, identify the cell cycle stages, identify c...

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Bibliographic Details
Main Authors: Zehua Liu, Huazhe Lou, Kaikun Xie, Hao Wang, Ning Chen, Oscar M. Aparicio, Michael Q. Zhang, Rui Jiang, Ting Chen
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00039-z