Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy.

Phenylbutyrate counteracts Shigella mediated downregulation of cathelicidin in rabbit lung and intestinal epithelia: a potential therapeutic strategy.

BACKGROUND: Cathelicidins and defensins are endogenous antimicrobial peptides (AMPs) that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB) reduces clinical severity and counteracts the downregulat...

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Main Authors: Protim Sarker, Sultan Ahmed, Snigdha Tiash, Rokeya Sultana Rekha, Roger Stromberg, Jan Andersson, Peter Bergman, Gudmundur H Gudmundsson, Birgitta Agerberth, Rubhana Raqib
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3108617?pdf=render

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http://europepmc.org/articles/PMC3108617?pdf=render

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