Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition

Cbl Negatively Regulates NLRP3 Inflammasome Activation through GLUT1-Dependent Glycolysis Inhibition

Activation of the nod-like receptor 3 (NLRP3) inflammasomes is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Cbl plays a pivotal role in suppressing NLRP3 inflammasome activation by inhibiting Pyk2-mediated apoptosis-assoc...

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Bibliographic Details
Main Authors: Hsin-Chung Lin, Yu-Jen Chen, Yau-Huei Wei, Yu-Ting Chuang, Su-Heng Hsieh, Jing-Yu Hsieh, Yi-Lin Hsieh, David M. Ojcius, Kuo-Yang Huang, I-Che Chung, Sheng-Ning Yuan, Yu-Sun Chang, Lih-Chyang Chen
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Cbl
NLRP3
inflammasome
glycolysis
GLUT1
Online Access:https://www.mdpi.com/1422-0067/21/14/5104

Internet

https://www.mdpi.com/1422-0067/21/14/5104

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