m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation

m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation

Abstract Background Dynamic N6-methyladenosine (m6A) RNA modification generated and erased by N6-methyltransferases and demethylases regulates gene expression, alternative splicing and cell fate. Ocular melanoma, comprising uveal melanoma (UM) and conjunctival melanoma (CM), is the most common prima...

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Bibliographic Details
Main Authors: Ruobing Jia, Peiwei Chai, Shanzheng Wang, Baofa Sun, Yangfan Xu, Ying Yang, Shengfang Ge, Renbing Jia, Yun-Gui Yang, Xianqun Fan
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Molecular Cancer
Subjects:
m6A
Melanoma
HINT2
Translation
Tumorigenesis
Online Access:http://link.springer.com/article/10.1186/s12943-019-1088-x

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http://link.springer.com/article/10.1186/s12943-019-1088-x

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