The biology of MDR1-P-glycoprotein (MDR1-Pgp) in designing functional antibody drug conjugates (ADCs): the experience of gemtuzumab ozogamicin
BACKGROUND: The treatment of cancer remains a formidable challenge owing to the difficulties in differentiating tumor cells from healthy cells to ameliorate the disease without causing intolerable toxicity to patients. In addition, the emergence of MDR1-Pgp mediated multi-drug resistance (MDR) it is...
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Format: | Article |
Language: | English |
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Istituto Superiore di Sanità
2013-06-01
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Series: | Annali dell'Istituto Superiore di Sanità |
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Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0021-25712013000200008&lng=en&tlng=en |