Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats

Effect of Melatonin on Rat Heart Mitochondria in Acute Heart Failure in Aged Rats

Excessive generation of reactive oxygen species (ROS) in mitochondria and the opening of the nonselective mitochondrial permeability transition pore are important factors that promote cardiac pathologies and dysfunction. The hormone melatonin (MEL) is known to improve the functional state of mitocho...

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Bibliographic Details
Main Authors: Irina Odinokova, Yulia Baburina, Alexey Kruglov, Irina Fadeeva, Alena Zvyagina, Linda Sotnikova, Vladimir Akatov, Olga Krestinina
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin
permeability transition pore
rat heart mitochondria
acute heart failure
aging
ROS production
2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase)
voltage-dependent anion channel (VDAC)
Online Access:http://www.mdpi.com/1422-0067/19/6/1555

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http://www.mdpi.com/1422-0067/19/6/1555

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