Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet

Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet

Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE−/−) mice. Male ApoE−/− mice received vehicle (control), low-level l...

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Bibliographic Details
Main Authors: Belal Chami, Farjaneh Hossain, Thomas W. Hambly, Xiaoping Cai, Roshanak Aran, Genevieve Fong, Abigail Vellajo, Nathan J.J Martin, XiaoSuo Wang, Joanne M. Dennis, Arpeeta Sharma, Waled A. Shihata, Jaye P. F. Chin-Dusting, Judy B. de Haan, Alexandra Sharland, Carolyn L. Geczy, Ben Freedman, Paul K. Witting
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
endothelial function
inflammation
nitric oxide
acute-phase protein
renal dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00380/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00380/full

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