GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.

GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.

Limited information is available on the brain expression and role of GPR35, a Gi/o coupled receptor activated by kynurenic acid (KYNA). In mouse cultured astrocytes, we detected GPR35 transcript using RT-PCR and we found that KYNA (0.1 to 100 µM) decreased forskolin (FRSK)-induced cAMP production (p...

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Bibliographic Details
Main Authors: Rolando Berlinguer-Palmini, Alessio Masi, Roberto Narducci, Leonardo Cavone, Dario Maratea, Andrea Cozzi, Maria Sili, Flavio Moroni, Guido Mannaioni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312407/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312407/?tool=EBI

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