Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase

Human lung adenocarcinoma exhibits a propensity for de-differentiation, complicating diagnosis and treatment, and predicting poorer patient survival. In genetically engineered mouse models of lung cancer, expression of the BRAFV600E oncoprotein kinase initiates the growth of benign tumors retaining...

Full description

Bibliographic Details
Main Authors: J Edward van Veen, Michael Scherzer, Julia Boshuizen, Mollee Chu, Annie Liu, Allison Landman, Shon Green, Christy Trejo, Martin McMahon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
lung adenocarcinoma
BRAF
PI3K
de-differentiation
PGC1a
Online Access:https://elifesciences.org/articles/43668

Internet

https://elifesciences.org/articles/43668

Similar Items