Concerted Transcriptional Regulation by BRCA1 and COBRA1 in Breast Cancer Cells

<p>Cofactor of BRCA1 (COBRA1) was first identified as a protein that binds to the breast cancer susceptibility gene product BRCA1. COBRA1 modulates estrogen-dependent and independent transcription and suppresses the growth of breast cancer cells. Its expression is significantly reduced in meta...

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Bibliographic Details
Main Author: Sarah E. Aiyar, HyungJun Cho, Jae Lee, Rong Li
Format: Article
Language:English
Published: Ivyspring International Publisher 2007-01-01
Series:International Journal of Biological Sciences
Online Access:http://www.biolsci.org/v03p0486.htm