mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico

mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico

Hepatocellular carcinoma (HCC) is ranked the third deadliest cancer worldwide whose molecular pathogenesis is not fully understood. Although deregulated metabolic pathways have been implicated in HCC onset and progression, the mechanisms triggering this metabolic imbalance are yet to be explored. He...

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Bibliographic Details
Main Authors: Kashif Rafiq Zahid, Shun Yao, Abdur Rehman Raza Khan, Umar Raza, Deming Gou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
tumor progression
metabolic imbalance
mTOR signaling
alcohol metabolism
ADH1A
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01000/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01000/full

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