Whole-Genome Sequencing Identifies a Novel Variation of WAS Gene Coordinating With Heterozygous Germline Mutation of APC to Enhance Hepatoblastoma Oncogenesis

Whole-Genome Sequencing Identifies a Novel Variation of WAS Gene Coordinating With Heterozygous Germline Mutation of APC to Enhance Hepatoblastoma Oncogenesis

Hepatoblastoma (HB), a leading primary hepatic malignancy in children, originates from primitive hepatic stem cells. This study aimed to uncover the genetic variants that are responsible for HB oncogenesis. One family, which includes the healthy parents, and two brothers affected by HB, was recruite...

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Bibliographic Details
Main Authors: Li Zhang, Yaqiong Jin, Kai Zheng, Huanmin Wang, Shen Yang, Chenkai Lv, Wei Han, Yongbo Yu, Yeran Yang, Di Geng, Hui Yang, Tieliu Shi, Yongli Guo, Xin Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Genetics
Subjects:
hepatoblastoma
whole-genome sequencing
Wiskott–Aldrich syndrome (WAS)
adenomatous polyposis coli (APC)
cancer predisposition gene
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00668/full

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https://www.frontiersin.org/article/10.3389/fgene.2018.00668/full

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