ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis – A Controversial Role of Protein Disulphide Isomerase

ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis – A Controversial Role of Protein Disulphide Isomerase

Accumulation of proteins in aberrant conformation occurs in many neurodegenerative diseases. Furthermore, dysfunctions in protein handling in endoplasmic reticulum (ER) and the following ER stress have been implicated in a vast number of diseases, such as amyotrophic lateral sclerosis (ALS). During...

Full description

Bibliographic Details
Main Authors: Merja eJaronen, Gundars eGoldsteins, Jari eKoistinaho
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Oxidative Stress
motoneuron
glia
neurodegeneration
ALS
er stress
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00402/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00402/full

Similar Items