Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.

Binomial mitotic segregation of MYCN-carrying double minutes in neuroblastoma illustrates the role of randomness in oncogene amplification.

Amplification of the oncogene MYCN in double minutes (DMs) is a common finding in neuroblastoma (NB). Because DMs lack centromeric sequences it has been unclear how NB cells retain and amplify extrachromosomal MYCN copies during tumour development.We show that MYCN-carrying DMs in NB cells transloca...

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Bibliographic Details
Main Authors: Gisela Lundberg, Anders H Rosengren, Ulf Håkanson, Henrik Stewénius, Yuesheng Jin, Ylva Stewénius, Sven Påhlman, David Gisselsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2518122?pdf=render

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http://europepmc.org/articles/PMC2518122?pdf=render

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