The adjustment of γ-aminobutyric acidA tonic subunits in Huntington's disease: from transcription to translation to synaptic levels into the neostriatum

The adjustment of γ-aminobutyric acidA tonic subunits in Huntington's disease: from transcription to translation to synaptic levels into the neostriatum

γ-Aminobutyric acid (GABA), plays a key role in all stages of life, also is considered the main inhibitory neurotransmitter. GABA activates two kind of membrane receptors known as GABAA and GABAB, the first one is responsible to render tonic inhibition by pentameric receptors containing α4−6, β3, δ,...

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Bibliographic Details
Main Authors: Abraham Rosas-Arellano, Argel Estrada-Mondragón, Carola A Mantellero, Carlos Tejeda-Guzmán, Maite A Castro
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
GABAA; extrasynaptic and perisynaptic γ-aminobutyric acidA receptors; striatum; R6/1
R6/2
HdhQ92
HdhQ111
HdhQ150
N171-82Q and YAC128 HD transgenics mice models; chorea; mutant huntingtin; inhibitory neurotransmission; D1 medium sized spiny neurons; D2 medium sized spiny neurons
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=4;spage=584;epage=590;aulast=Rosas-Arellano

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=4;spage=584;epage=590;aulast=Rosas-Arellano

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