Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor

Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor

Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver. We previously showed that human BSEP was isoform-dependently regulated by FXR and diminished with alte...

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Bibliographic Details
Main Authors: Xiulong Song, Yuan Chen, Leila Valanejad, Rajani Kaimal, Bingfang Yan, Matthew Stoner, Ruitang Deng
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Journal of Lipid Research
Subjects:
bile acid transporter
canalicular secretion
gene transcription
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350549

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http://www.sciencedirect.com/science/article/pii/S0022227520350549

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