Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons

Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons

Peripheral nerve injury triggers the activation of RhoA in spinal motor and peripheral sensory neurons. RhoA activates a number of effector proteins including the Rho-associated kinase, ROCK, which targets the cytoskeleton and leads to inhibition of neurite outgrowth. Blockade of the Rho/ROCK pathwa...

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Bibliographic Details
Main Authors: Maria eAuer, Ruediger eSchweigreiter, Barbara eHausott, Sitthisak eThongrong, Markus eHöltje, Ingo eJust, Christine eBandtlow, Lars eKlimaschewski
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
dorsal root ganglia
RhoA
axon regeneration
kinases
exoenzyme
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00043/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2012.00043/full

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