Butyrate induces apoptosis in murine macrophages via caspase-3, but independent of autocrine synthesis of tumor necrosis factor and nitric oxide

We demonstrated that 4 mM butyrate induces apoptosis in murine peritoneal macrophages in a dose- and time-dependent manner as indicated by studies of cell viability, flow cytometric analysis of annexin-V binding, DNA ladder pattern and the determination of hypodiploid DNA content. The activity of ca...

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Bibliographic Details
Main Authors: Ramos M.G., Rabelo F.L.A., Duarte T., Gazzinelli R.T., Alvarez-Leite J.I.
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2002-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200004