Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits

Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits

Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg−1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determ...

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Bibliographic Details
Main Authors: Yu Chun, Li Donghao, Li Zhongyan, Yu Donghui, Zhai Guijuan
Format: Article
Language:English
Published: Sciendo 2021-09-01
Series:Acta Pharmaceutica
Subjects:
sacubitril
valsartan
doxorubicin-heart failure
inflammation
oxidative stress
natriuretic peptide
Online Access:https://doi.org/10.2478/acph-2021-0030

Internet

https://doi.org/10.2478/acph-2021-0030

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