COMPUTATIONAL APPROACHES FOR RATIONAL DESIGN OF PROTEINS WITH NOVEL FUNCTIONALITIES

COMPUTATIONAL APPROACHES FOR RATIONAL DESIGN OF PROTEINS WITH NOVEL FUNCTIONALITIES

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Proteins are the most multifaceted macromolecules in living systems and have various important functions, including structural, catalytic, sensory, and regulatory functions. Rational design of enzymes is a great challenge to our understanding of protein structure and physical chemistry and has numer...

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Bibliographic Details
Main Authors: Manish Kumar Tiwari, Ranjitha Singh, Raushan Kumar Singh, In-Won Kim, Jung-Kul Lee
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Computational and Structural Biotechnology Journal
Subjects:
De novo protein design
computational protein design
designed therapeutic proteins
metalloproteins
ROSETTA
K* algorithm
DEZYMER
ORBIT
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037014600805

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http://www.sciencedirect.com/science/article/pii/S2001037014600805

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