A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells

A Fluorescent Glucose Transport Assay for Screening SGLT2 Inhibitors in Endogenous SGLT2-Expressing HK-2 Cells

Abstract The sodium-dependent glucose transporters 2 (SGLT2) plays important role in renal reabsorption of urinal glucose back to plasma for maintaining glucose homeostasis. The approval of SGLT2 inhibitors for treatment of type 2 diabetes highlights the SGLT2 as a feasible and promising drug target...

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Bibliographic Details
Main Authors: Yan-Ting Lu, Xiu-Li Ma, Yu-Hui Xu, Jing Hu, Fang Wang, Wan-Ying Qin, Wen-Yong Xiong
Format: Article
Language:English
Published: SpringerOpen 2018-11-01
Series:Natural Products and Bioprospecting
Subjects:
SGLT2 inhibitor
2-NBDG
HK-2
Glucose uptake
Online Access:http://link.springer.com/article/10.1007/s13659-018-0188-4

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http://link.springer.com/article/10.1007/s13659-018-0188-4

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