Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis.

Metabolic regulation of invadopodia and invasion by acetyl-CoA carboxylase 1 and de novo lipogenesis.

Invadopodia are membrane protrusions that facilitate matrix degradation and cellular invasion. Although lipids have been implicated in several aspects of invadopodia formation, the contributions of de novo fatty acid synthesis and lipogenesis have not been defined. Inhibition of acetyl-CoA carboxyla...

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Bibliographic Details
Main Authors: Kristen E N Scott, Frances B Wheeler, Amanda L Davis, Michael J Thomas, James M Ntambi, Darren F Seals, Steven J Kridel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3253107?pdf=render

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http://europepmc.org/articles/PMC3253107?pdf=render

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