Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs

Rlim-Dependent and -Independent Pathways for X Chromosome Inactivation in Female ESCs

During female mouse embryogenesis, two forms of X chromosome inactivation (XCI) ensure dosage compensation from sex chromosomes. Beginning at the four-cell stage, imprinted XCI (iXCI) exclusively silences the paternal X (Xp), and this pattern is maintained in extraembryonic cell types. Epiblast cell...

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Bibliographic Details
Main Authors: Feng Wang, Kurtis N. McCannell, Ana Bošković, Xiaochun Zhu, JongDae Shin, Jun Yu, Judith Gallant, Meg Byron, Jeanne B. Lawrence, Lihua J. Zhu, Stephen N. Jones, Oliver J. Rando, Thomas G. Fazzio, Ingolf Bach
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
Rlim
Rnf12
Xist
X chromosome inactivation
XCI
XCI regulation
Rlim-independent XCI
ESC
EB differentiation
physiological oxygen levels
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717318004

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http://www.sciencedirect.com/science/article/pii/S2211124717318004

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