Exploring the full natural diversity of single amino acid exchange reveals that 40–60% of BSLA positions improve organic solvents resistance

Exploring the full natural diversity of single amino acid exchange reveals that 40–60% of BSLA positions improve organic solvents resistance

Abstract Objectives Protein engineering has been employed to successfully improve organic solvent resistance of enzymes. Exploration of nature’s full potential (how many beneficial positions/beneficial substitutions of the target enzyme) to improve organic solvent resistance of enzymes by a systemat...

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Bibliographic Details
Main Authors: Victorine Josiane Frauenkron-Machedjou, Alexander Fulton, Jing Zhao, Lina Weber, Karl-Erich Jaeger, Ulrich Schwaneberg, Leilei Zhu
Format: Article
Language:English
Published: SpringerOpen 2018-01-01
Series:Bioresources and Bioprocessing
Subjects:
BSLA
Directed evolution
Protein engineering
Site saturation mutagenesis
Organic solvents resistance
Online Access:http://link.springer.com/article/10.1186/s40643-017-0188-y

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http://link.springer.com/article/10.1186/s40643-017-0188-y

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