Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

Arterial pulsations are thought to drive CSF flow through perivascular spaces (PVSs), but this has never been quantitatively shown. Using particle tracking to quantify CSF flow velocities in PVSs of live mice, the authors show that flow speeds match the instantaneous speeds of the pulsing artery wal...

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Main Authors:	Humberto Mestre, Jeffrey Tithof, Ting Du, Wei Song, Weiguo Peng, Amanda M. Sweeney, Genaro Olveda, John H. Thomas, Maiken Nedergaard, Douglas H. Kelley
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-07318-3

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spelling	doaj-31e452ba634047b983250f695ea051392021-05-11T09:44:32ZengNature Publishing GroupNature Communications2041-17232018-11-01911910.1038/s41467-018-07318-3Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertensionHumberto Mestre0Jeffrey Tithof1Ting Du2Wei Song3Weiguo Peng4Amanda M. Sweeney5Genaro Olveda6John H. Thomas7Maiken Nedergaard8Douglas H. Kelley9Center for Translational Neuromedicine, University of Rochester Medical CenterDepartment of Mechanical Engineering, University of RochesterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterCenter for Translational Neuromedicine, University of Rochester Medical CenterDepartment of Mechanical Engineering, University of RochesterCenter for Translational Neuromedicine, University of Rochester Medical CenterDepartment of Mechanical Engineering, University of RochesterArterial pulsations are thought to drive CSF flow through perivascular spaces (PVSs), but this has never been quantitatively shown. Using particle tracking to quantify CSF flow velocities in PVSs of live mice, the authors show that flow speeds match the instantaneous speeds of the pulsing artery walls that form the inner boundaries of the PVSs.https://doi.org/10.1038/s41467-018-07318-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Humberto Mestre Jeffrey Tithof Ting Du Wei Song Weiguo Peng Amanda M. Sweeney Genaro Olveda John H. Thomas Maiken Nedergaard Douglas H. Kelley
spellingShingle	Humberto Mestre Jeffrey Tithof Ting Du Wei Song Weiguo Peng Amanda M. Sweeney Genaro Olveda John H. Thomas Maiken Nedergaard Douglas H. Kelley Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension Nature Communications
author_facet	Humberto Mestre Jeffrey Tithof Ting Du Wei Song Weiguo Peng Amanda M. Sweeney Genaro Olveda John H. Thomas Maiken Nedergaard Douglas H. Kelley
author_sort	Humberto Mestre
title	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_short	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_full	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_fullStr	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_full_unstemmed	Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
title_sort	flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-11-01
description	Arterial pulsations are thought to drive CSF flow through perivascular spaces (PVSs), but this has never been quantitatively shown. Using particle tracking to quantify CSF flow velocities in PVSs of live mice, the authors show that flow speeds match the instantaneous speeds of the pulsing artery walls that form the inner boundaries of the PVSs.
url	https://doi.org/10.1038/s41467-018-07318-3
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Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension

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