Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster.

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster.

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease. However, the mechanisms that lead to loss of barrier function remain poorly understood. Using D. melanogaster, we demonstrate that dietary restriction (DR) slows the age-related decline in intestinal inte...

Full description

Bibliographic Details
Main Authors: Kazutaka Akagi, Kenneth A Wilson, Subhash D Katewa, Mauricio Ortega, Jesse Simons, Tyler A Hilsabeck, Subir Kapuria, Amit Sharma, Heinrich Jasper, Pankaj Kapahi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6233930?pdf=render

Internet

http://europepmc.org/articles/PMC6233930?pdf=render

Similar Items