Attenuation of a Pathogenic Mycoplasma Strain by Modification of the obg Gene by Using Synthetic Biology Approaches

Attenuation of a Pathogenic Mycoplasma Strain by Modification of the obg Gene by Using Synthetic Biology Approaches

Animal diseases due to mycoplasmas are a major cause of morbidity and mortality associated with economic losses for farmers all over the world. Currently used mycoplasma vaccines exhibit several drawbacks, including low efficacy, short time of protection, adverse reactions, and difficulty in differe...

Full description

Bibliographic Details
Main Authors: Carole Lartigue, Yanina Valverde Timana, Fabien Labroussaa, Elise Schieck, Anne Liljander, Flavio Sacchini, Horst Posthaus, Brigitte Batailler, Pascal Sirand-Pugnet, Sanjay Vashee, Joerg Jores, Alain Blanchard
Format: Article
Language:English
Published: American Society for Microbiology 2019-05-01
Series:mSphere
Subjects:
GTPase Obg
Mycoplasma
Saccharomyces cerevisiae
attenuated strain
genome engineering
genome transplantation
temperature sensitivity
vaccines
Online Access:https://doi.org/10.1128/mSphere.00030-19

Internet

https://doi.org/10.1128/mSphere.00030-19

Similar Items