The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3
The NLRP3 inflammasome controls the response of the host to pathogens; precise regulation is required to limit autoimmune diseases. Here, the authors identify the E3 ligase TRIM31 that aids the ubiquitin-mediated proteasomal degradation of NLRP3, which may be a therapeutic target for alleviating dis...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13727 |