Effects of Tumor Necrosis Factor-α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy

Effects of Tumor Necrosis Factor-α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy

Background/Aims: Tumor necrosis factor (TNF)-α is believed to play a role in diabetic kidney disease. This study explores the specific effects of TNF-α with regard to nephropathy-relevant parameters in the podocyte. Methods: Cultured mouse podocytes were treated with recombinant TNF-α and assayed fo...

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Bibliographic Details
Main Authors: Choon Hee Chung, Jingyi Fan, Eun Young Lee, Jeong Suk Kang, Seung Joo Lee, Petr E. Pyagay, Charbel C. Khoury, Tet-Kin Yeo, Mark F. Khayat, Amy Wang, Sheldon Chen
Format: Article
Language:English
Published: Karger Publishers 2015-02-01
Series:Nephron Extra
Subjects:
Diabetic rodent model
Akt or protein kinase B
Albuminuria
Nuclear factor-kappaB
Phosphatidylinositol 3-kinase
TNF receptor 2
Online Access:http://www.karger.com/Article/FullText/369576

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http://www.karger.com/Article/FullText/369576

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