Study of Acute Toxicity and Irritant Effect of Nasal Spray Naltrexone Hydrochloride

Introduction. Acute toxicity of naltrexone hydrochloride nasal spray during intragastric administration to mice and local irritant effect on rabbits was studied. At all stages of the experiment, observations were made on the General condition of the animals. The state of homeostasis was evaluated us...

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Bibliographic Details
Main Authors: Yu. M. Domnina, V. V. Suslov, S. A. Kedik, D. A. Akhmedova, A. P. Malkova
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2021-05-01
Series:Разработка и регистрация лекарственных средств
Subjects:
Online Access:https://www.pharmjournal.ru/jour/article/view/856