Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines

Frontotemporal dementia mutant Tau promotes aberrant Fyn nanoclustering in hippocampal dendritic spines

The Src kinase Fyn plays critical roles in memory formation and Alzheimer’s disease. Its targeting to neuronal dendrites is regulated by Tau via an unknown mechanism. As nanoclustering is essential for efficient signaling, we used single-molecule tracking to characterize the nanoscale distribution o...

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Bibliographic Details
Main Authors: Pranesh Padmanabhan, Ramón Martínez-Mármol, Di Xia, Jürgen Götz, Frédéric A Meunier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
Tau
Fyn
nanoclusters
super-resolution
signalling
Online Access:https://elifesciences.org/articles/45040

Internet

https://elifesciences.org/articles/45040

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