C-terminal low-complexity sequence repeats of Mycobacterium smegmatis Ku modulate DNA binding

C-terminal low-complexity sequence repeats of Mycobacterium smegmatis Ku modulate DNA binding

Ku protein is an integral component of the NHEJ (non-homologous end-joining) pathway of DSB (double-strand break) repair. Both eukaryotic and prokaryotic Ku homologues have been characterized and shown to bind DNA ends. A unique feature of Mycobacterium smegmatis Ku is its basic C-terminal tail that...

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Bibliographic Details
Main Authors: Ambuj K. Kushwaha, Anne Grove
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-01-01
Series:Bioscience Reports
Subjects:
DNA binding
electrophoretic mobility-shift assay
Ku protein
low-complexity repeats
non-homologous end-joining (NHEJ)
Online Access:http://www.bioscirep.org/bsr/033/e016/bsr033e016.htm

Internet

http://www.bioscirep.org/bsr/033/e016/bsr033e016.htm

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