A lymphodepleted non‐human primate model for the assessment of acute on‐target and off‐tumor toxicity of human chimeric antigen receptor‐T cells

A lymphodepleted non‐human primate model for the assessment of acute on‐target and off‐tumor toxicity of human chimeric antigen receptor‐T cells

Abstract Objectives Chimeric antigen receptor (CAR)‐T cell therapy possesses the potential to cause unexpected on‐target toxicities that may be life‐threatening. Non‐human primates (NHPs) share considerable structural homology and expression profiles of most proteins with humans and are therefore ut...

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Bibliographic Details
Main Authors: Shigeki Yagyu, Hidemi Mochizuki, Kumiko Yamashima, Hiroshi Kubo, Shoji Saito, Miyuki Tanaka, Kengo Sakamoto, Akihito Shimoi, Yozo Nakazawa
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
CAR‐T cells
cell therapy
lymphodepletion
non‐human primate
off‐target toxicity
on‐target toxicity
Online Access:https://doi.org/10.1002/cti2.1291

Internet

https://doi.org/10.1002/cti2.1291

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