Mechanism of the mitogenic influence of hyperinsulinemia
<p>Abstract</p> <p>Either endogenous or exogenous hyperinsulinemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras protein. Increased availability of farnesylated Ras at the plasma membra...
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| Format: | Article |
| Language: | English |
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BMC
2011-06-01
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| Series: | Diabetology & Metabolic Syndrome |
| Online Access: | http://www.dmsjournal.com/content/3/1/10 |