Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I[S]

Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I[S]

HDL removes cell cholesterol and protects against atherosclerosis. ApoA-I provides a flexible structural scaffold and an important functional ligand on the HDL surface. We propose structural models for apoA-IMilano (R173C) and apoA-IParis (R151C) mutants that show high cardioprotection despite low H...

Full description

Bibliographic Details
Main Authors: Olga Gursky, Martin K. Jones, Xiaohu Mei, Jere P. Segrest, David Atkinson
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Journal of Lipid Research
Subjects:
Milano and Paris mutations
double-belt and trefoil/tetrafoil conformations
protein-lipid interactions
protein dynamics and function
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356789

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520356789

Similar Items