Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes in vitro and in vivo

Treatment With Naringenin Elevates the Activity of Transcription Factor Nrf2 to Protect Pancreatic β-Cells From Streptozotocin-Induced Diabetes in vitro and in vivo

Chronic hyperglycemia and unusually high oxidative stress are the key contributors for diabetes in humans. Since nuclear factor E2-related factor 2 (Nrf2) controls the expression of antioxidant- and detoxification genes, it is hypothesized that targeted activation of Nrf2 using phytochemicals is lik...

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Bibliographic Details
Main Authors: Rashmi Rajappa, Dornadula Sireesh, Magesh B. Salai, Kunka M. Ramkumar, Suryanarayanan Sarvajayakesavulu, SubbaRao V. Madhunapantula
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
diabetes
streptozotocin
naringenin
Nrf2
MIN6 cells
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01562/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01562/full

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