Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.

Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.

Excitotoxicity due to glutamate receptor over-activation is one of the key mediators of neuronal death after an ischemic insult. Therefore, a major function of astrocytes is to maintain low extracellular levels of glutamate. The ability of astrocytic glutamate transporters to regulate the extracellu...

Full description

Bibliographic Details
Main Authors: Aixa F Rivera-Pagán, David E Rivera-Aponte, Katya V Melnik-Martínez, Astrid Zayas-Santiago, Lilia Y Kucheryavykh, Antonio H Martins, Luis A Cubano, Serguei N Skatchkov, Misty J Eaton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4401746?pdf=render

Internet

http://europepmc.org/articles/PMC4401746?pdf=render

Similar Items