Computational design of environmental sensors for the potent opioid fentanyl

Computational design of environmental sensors for the potent opioid fentanyl

We describe the computational design of proteins that bind the potent analgesic fentanyl. Our approach employs a fast docking algorithm to find shape complementary ligand placement in protein scaffolds, followed by design of the surrounding residues to optimize binding affinity. Co-crystal structure...

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Bibliographic Details
Main Authors: Matthew J Bick, Per J Greisen, Kevin J Morey, Mauricio S Antunes, David La, Banumathi Sankaran, Luc Reymond, Kai Johnsson, June I Medford, David Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
protein design
biosensors
transgenic plants
Online Access:https://elifesciences.org/articles/28909

Internet

https://elifesciences.org/articles/28909

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