Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence.

Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence.

Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells i...

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Bibliographic Details
Main Authors: Maria Pino, Sara Paganini, Claire Deleage, Kartika Padhan, Justin L Harper, Colin T King, Luca Micci, Barbara Cervasi, Joseph C Mudd, Kiran P Gill, Sherrie M Jean, Kirk Easley, Guido Silvestri, Jacob D Estes, Constantinos Petrovas, Michael M Lederman, Mirko Paiardini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008081

Internet

https://doi.org/10.1371/journal.ppat.1008081

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