The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel

The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel

Summary: Repaglinide (RPG) is a short-acting insulin secretagogue widely prescribed for the treatment of type 2 diabetes. It boosts insulin secretion by inhibiting the pancreatic ATP-sensitive potassium channel (KATP). However, the mechanisms by which RPG binds to the KATP channel are poorly underst...

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Bibliographic Details
Main Authors: Dian Ding, Mengmeng Wang, Jing-Xiang Wu, Yunlu Kang, Lei Chen
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719305236

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http://www.sciencedirect.com/science/article/pii/S2211124719305236

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