Efficient production of (S)-1-phenyl-1,2-ethanediol using xylan as co-substrate by a coupled multi-enzyme Escherichia coli system

Efficient production of (S)-1-phenyl-1,2-ethanediol using xylan as co-substrate by a coupled multi-enzyme Escherichia coli system

Abstract Background (S)-1-phenyl-1,2-ethanediol is an important chiral intermediate in the synthesis of liquid crystals and chiral biphosphines. (S)-carbonyl reductase II from Candida parapsilosis catalyzes the conversion of 2-hydroxyacetophenone to (S)-1-phenyl-1,2-ethanediol with NADPH as a cofact...

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Bibliographic Details
Main Authors: Junchao Rao, Rongzhen Zhang, Guanyu Xu, Lihong Li, Yan Xu
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Microbial Cell Factories
Subjects:
(S)-carbonyl reductase II
Glucose dehydrogenase mutant Ala258Phe
Endo-β-1,4-xylanase 2
Multi-enzyme system
Cofactor regeneration
Chiral synthesis
Online Access:http://link.springer.com/article/10.1186/s12934-020-01344-x

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http://link.springer.com/article/10.1186/s12934-020-01344-x

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