Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation

Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation

In chronic liver diseases, regardless of their etiology, the development of fibrosis is the first step toward the progression to cirrhosis, portal hypertension, and hepatocellular carcinoma. Hepatic stellate cells (HSCs) are the main profibrogenic cells that promote the pathogenesis of liver fibrosi...

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Bibliographic Details
Main Authors: Yuh-Ching Twu, Tzong-Shyuan Lee, Yun-Lian Lin, Shih-Ming Hsu, Yuan-Hsi Wang, Chia-Yu Liao, Chung-Kwe Wang, Yu-Chih Liang, Yi-Jen Liao
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:International Journal of Molecular Sciences
Subjects:
Niemann-Pick type C2
hepatic stellate cells
free cholesterol
transforming growth factor-β1
liver fibrosis
Online Access:http://www.mdpi.com/1422-0067/17/7/1122

Internet

http://www.mdpi.com/1422-0067/17/7/1122

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